Anti-HRX (center) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

General description

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.

Immunogen

HRX (HRX_HUMAN, 2591-2625)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human HRX.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.